Clinical variables that help in predicting the presence of autoantibodies in patients with acute encephalitis

ObjectiveTo identify clinical variables that could predict the presence of autoantibodies in patients with acute encephalitis.MethodsAn observational, retrospective study from May 2011 to 2017. Clinical, EEG, brain MRI data, and antibodies against human neuronal antigens (NMDAR, GABAR, AMPAR, LGI1, CASPR2, GAD) 158 criteria for possible autoimmune encephalitis were analyzed create a predictive model this disease.ResultsWe samples, which 18 cases positive anti-NMDAR, 2 anti-LGI1, anti-GAD. Seven NMDAR children, 12 female. Behavioral disorder, epileptic seizures, movement altered level consciousness frequent symptoms >75 % sensitivity anti-NMDAR patients. Other symptoms, such as language psychosis, hypoventilation, wake sleep cycle, cognitive impairment, had >55 %. Abnormal EEG findings high (99.4 %). Brain suggestive was observed 7 NMDAR. CSF reported receptor (sensitivity 70.6 With these we obtained 70 specificity 81 (ROC Area 82 However, patient subacute may have an cause, should include manifestations behavioral dysautonomia, alteration cycle. Children significantly more likely than adults experience chorea status epilepticus (p < 0.05).ConclusionsAnti-NMDAR females children. The repertoire children is different adults. changes, disorders, consciousness, cycle predicted our series.